User:Herb5902/Thiamine

• Elevated cytosolic glucose concentrations lead to elevated triosephosphates levels and diabetic complications.
• These triosephosphates are removed via the reductive pentosephosphate pathway which is impaired by mild thiamine deficiency.
• Thiamine prevents nephropathy, neuropathy and retinopathy.
  • Marked reversals of increased diuresis and glucosuria without change in glycemic status.
  • 300 mg/day of thiamine reverses albuminuria [1]
• Prevents activation of protein kinase C.
• Prevents formation of advanced glycation end-products (AGE).