User:Herb5902/Gynostemma pentaphyllum

Jiaogulan (Southern Ginseng)

over 80 different saponins including GYPENOSIDES
actiponin
Ginsenosides

Benefits:

• Mitigates the Diabetic Nephropathy through Down-regulating mTOR
• Prevents and treats of acute renal failure by improving renal tubule congestion and renal tubule epithelial edema
• G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], and damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], that strongly activate AMPK
  • AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism
  • Damulins A and B also increases:
    • β-oxidation and
    • glucose uptake by
    • increasing GluT4 translocation
• Diabetes
  • improves insulin sensitivity
  • may also help in the production of insulin
• Activates AMPK and
• Inhibits the insulin regulator PTP1B
• Induces antioxidant enzymes
• Promotes the transcription factor NRF2
• Increases mitochondrial metabolism by activating the PGC-1α pathway
• Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway
• Allergies
  • boosts Th1 cell production by activating PPAR alpha
  • reduces histamine production
• anti-inflammatory
• REDUCTION OF HEADACHES
• Cancer (inducer of p53)
• Aging
• Exercise endurance

Adverse effects:

• Vomiting
• Diarrhea
• Constipation
• Dizziness
• Blurred vision
• Tinnitus

In addition to activating AMPK, Gynostemma pentaphyllum mitigates the Diabetic Nephropathy through downregulating mTOR. It prevents and treats of acute renal failure by improving renal tubule congestion and renal tubule epithelial edema.