Deleted:Parallel Genome Assembly
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Parallel Genome Assembly (PGA) is a hypothesis in the field of evolutionary biology proposing a mechanism by which the diversity of life could have arisen from the primordial pond. The theory was developed by Periannan Senapathy.[1]Template:Verify credibility
The modern evolutionary synthesis, the expanded form of Charles Darwin's theory of evolution, states that all life originated from a primitive organism, presumably a single celled organism. Senapathy argues that this evolutionary model is fundamentally flawed as there is very little commonality among genes from organisms from various branches in the tree of life, therefore a single primitive organism cannot be a last universal common ancestor. Further, Senapathy argues that evolving a new gene through random mutations could take as long as 1035</sub> years. Senapathy contends that genomes of all organisms are composed of several genes, each of which may have a different evolutionary history.[2]Template:Verify credibility
According to PGA, several complex eukaryotic genomes containing split genes could have easily[citation needed] arisen from the primordial pond, and that it was far more likely to have split genetic sequences containing short coding sequences interspersed with long sequences of non coding DNA within random genetic sequences in the primordial pond than simple prokaryotic genomes (which contain only coding sequences). Senapathy's research has shown that random genetic sequences have similar characteristics to long split genomes found in complex eukaryotic genomes. In addition, an impossible[citation needed] amount of DNA would be required for prokaryotic genomes to have developed directly from the primordial pond. According to this model, bacteria did not evolve into a eukaryote, nor did a eukaryote evolve into a complex multi-cellular life. Rather, complex genomes of multi-cellular organisms could have independently, and in parallel, developed from the pond. In this model, complex eukaryotic genomes would have in parallel risen first[clarification needed] from the primordial pond. Senapathy argues that PGA eliminates several classical dilemmas presented by the conventional linear branching evolutionary theories such as the those in On the Origin of Species.[2]Template:Verify credibility
Selected publications on PGA
- Regulapati R, Bhasi A, Singh CK, Senapathy P (2008). Field, Dawn. ed. "Origination of the split structure of spliceosomal genes from random genetic sequences". PLoS ONE 3 (10): e3456. doi:10.1371/journal.pone.0003456. PMC 2565106. PMID 18941625.
- Senapathy P (June 1995). "Introns and the origin of protein-coding genes". Science 268 (5215): 1366–7; author reply 1367–9. doi:10.1126/science.7761858. PMID 7761858. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=7761858.
- Senapathy P (February 1988). "Possible evolution of splice-junction signals in eukaryotic genes from stop codons". Proc. Natl. Acad. Sci. U.S.A. 85 (4): 1129–33. doi:10.1073/pnas.85.4.1129. PMC 279719. PMID 3422483. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=3422483.
- Senapathy P (April 1986). "Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications". Proc. Natl. Acad. Sci. U.S.A. 83 (7): 2133–7. doi:10.1073/pnas.83.7.2133. PMC 323245. PMID 3457379. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=3457379.
See also
- Neutral theory of molecular evolution
- On the Origin of Species
- Abiogenesis
- Introduction to evolution
- Modern evolutionary synthesis
- Molecular evolution