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Cerberus is a creature from Greek mythology, depicted as a massive, three-headed dog who guards the entrance to the Underworld. The name has also been applied to various other identical creatures in works of fiction.
My Little Pony
My Little Pony: Friendship is Magic also features a creature/character named Cerberus, who is heavily inspired by the mythological creature; instead of the Underworld it guards the subterranean prison of Tartarus.